用免疫检查点抑制剂治疗患者的急性损伤:单中心回顾性研究
Ping Zhou1, Bing Liu2, Ning Shen1
1Department of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, China.
Renal failure
|March 11, 2024
概括
免疫检查点抑制剂相关的急性损伤 (ICI-AKI) 影响5.1%的中国癌症患者. 较低的基线功能和抗生素使用增加ICI-AKI风险,大约一半的患者恢复功能.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
- 免疫检查点抑制剂相关的急性损伤 (ICI-AKI) 是一种严重的并发症.
- 关于ICI-AKI在中国癌症患者群体中的数据有限.
研究的目的:
- 调查ICI-AKI的发生率,危险因素,临床特征和恢复.
- 在接受ICI治疗的中国癌症患者中分析ICI-AKI结果.
主要方法:
- 904名癌症患者接受ICI治疗的回顾性队列研究.
- 分析患者数据,包括基线特征和治疗结果.
- 多变量后勤回归用于识别ICI-AKI预测器.
主要成果:
- 在904名患者中,ICI-AKI的发病率为5.1% (46名).
- 较低的基线eGFR和抗生素使用与ICI-AKI风险增加有关.
- 在46%的患者中观察到脏恢复,43%的患者完全康复.
结论:
- 在接受ICI的中国癌症患者中,ICI-AKI是一个值得注意的并发症.
- 基线功能和同时使用抗生素是ICI-AKI的关键风险因素.
- 大约一半的ICI-AKI患者经历脏恢复.
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