柴油废气吸入的生物效应. 三,心血管功能 III,心血管功能
Kristine Krajnak1, Hong Kan2, Janet A Thompson2
1Physical Effects Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Inhalation toxicology
|March 11, 2024
概括
柴油废气 (DE) 吸入可导致老鼠急性心血管功能障碍,特别是在较高度下. 然而,大多数对血管和心脏功能的影响在暴露停止后的7天内恢复.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管生理学心血管生理学
背景情况:
- 柴油废气 (DE) 是由于颗粒物和烟雾而造成的职业和公共卫生危害.
- 发动机修改旨在减少DE排放,但对健康的影响需要持续调查.
研究的目的:
- 检查吸入柴油废气对心血管和外周血管功能的影响.
- 在雄性大鼠中,评估DE暴露后心脏和功能障碍的生物标志物.
主要方法:
- 雄性大鼠被暴露在0.2或1.0毫克/立方米的DE或过空气中,每天6小时,持续4天.
- 评估周围和心血管功能,包括血压和心脏输出.
- 对心脏和功能障碍和心脏/转录表达的评估生物标志物.
主要成果:
- 暴露于0.2mg/m3DE增加了暴露后的血压和心脏输出.
- 周围血管反应和转录表达的显著变化是最小的.
- 暴露于1.0mg/m3DE并没有引起主要的心血管或转录基因的改变.
结论:
- 来自二级发动机的柴油废气可以导致急性心血管功能障碍生物标志物.
- 大多数心血管和血管功能指标在暴露后7天内恢复到基线.
- 这些发现突显了DE诱导的心血管影响的短暂性质.
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