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Tatiana R Rosenblatt¹, Carolina A Chiou¹, Michael K Yoon¹

¹Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

Orbit (Amsterdam, Netherlands)

|March 11, 2024

概括

对于甲状腺眼病患者来说,teprotumumab在上眼收缩 (MRD1) 中提供了适度但显著的减少,并且长期持续的好处. 较高的初始眼收缩与治疗后更大的改善相关.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.

背景情况:

甲状腺眼病 (TED) 经常导致眼收缩,影响视力和生活质量.
与TED相关的眼收缩目前的治疗方法存在挑战.
在解决眼收缩方面,teprotumumab的疗效尚未得到充分证实.

研究的目的:

评估teprotumumab对甲状腺眼病患者上眼位置的影响.
为了评估在teprotumumab治疗后边缘反射距离-1 (MRD1) 的变化.

主要方法:

对完成了八次teprotumumab输注的患者进行了回顾性分析.
在治疗前,治疗后立即和长期随访时测量上眼位置的变化 (MRD1).
分析了影响MRD1减少的因素,包括治疗前的MRD1和.

主要成果:

在治疗后立即观察到MRD1的统计学显著减少,并在随访期间持续 (平均10.6个月).
大约58%的眼睛在治疗后立即显示MRD1的减少,平均为1.49毫米.
较高的治疗前MRD1与更高的减少的可能性和数量有关.
超过69%的眼睛在最长的随访期间保持稳定或改善了收缩能力,与治疗后的眼睛相比.

结论:

在大多数TED患者中,teprotumumab在上眼收缩方面提供了适度但显著的改善.
在随访期间,对MRD1的观察到的益处持续了.
眼收缩的改善程度似乎与收缩的最初严重程度有关.

关键词:

这就是为什么Teprotumumab.眼收缩眼收缩边缘反射距离-1 (MRD1) 是一个反射距离.预示性化预示性化甲状腺眼睛疾病甲状腺眼睛疾病

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