COVID-19 后的胆色素病变:系统性审查和流行率评估,揭示了对新兴眼睛实体的洞察力
Mona Mahmoud Elsakka1, Mostafa Hossam El Din Moawad2,3, Eman E Labeeb4
1Faculty of Pharmacy, Damanhur Univesity, Beheira, Egypt.
Seminars in ophthalmology
|March 11, 2024
概括
在COVID-19后的胆固醇蛋白质变异与皮质类固醇使用有关. 停用皮质类固醇在一些患者中改善了视力,但确切的关系尚不清楚.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- COVID-19已与各种眼部表现有关.
- 据报道,冠状腺和视网膜受到影响的病症冠状腺变,已在COVID-19感染后出现.
研究的目的:
- 为了调查COVID-19后的胆红蛋白病变发生情况.
- 分析人口,临床和治疗特征,重点关注皮质类固醇使用.
主要方法:
- 在PubMed,Cochrane,WOS和Scopus数据库中进行系统搜索 (2020年11月 - 2023年8月).
- 包括COVID-19患者的病例报告和病例系列.
- 使用Joanna Briggs研究所的批判性评估工具进行质量评估.
主要成果:
- 10名患者 (女性6名,男性4名,平均年龄36.5岁) 在COVID-19后发展出胆色素变异症.
- 七名患者 (70%) 之前曾使用过皮质类固醇;感染后6天至3个月出现症状.
- 诊断出中央血清性胆色素变异症 (70%) 和点状内胆色素变异症 (20%);大多数患者在停用皮质类固醇后视力敏度有所改善.
结论:
- 在COVID-19,胆红蛋白病变和皮质类固醇使用之间存在潜在的关联.
- 皮质类固醇的作用是复杂的,在不同情况下,在停止治疗和服用后都会出现症状改善.
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