通过母乳接触草甘除草剂对后代抗氧化状态,神经发育和行为的影响
Hammou Anarghou1,2, Hafsa Malqui3, Said Ihbour3
1Biological Engineering Laboratory, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Beni Mellal, Morocco. h.anarghou@gmail.com.
Naunyn-Schmiedeberg's archives of pharmacology
|March 11, 2024
概括
在发育过程中暴露于基于草甘的除草剂 (GBH) 会损害后代的神经发育和母亲的行为. 这项研究揭示了GBH.
科学领域:
- 神经科学是一个神经科学.
- 发育毒理学 发展毒理学
- 环境健康 环境健康
背景情况:
- 草甘基除草剂 (GBH) 是广泛使用的农药.
- 研究了GBH的神经毒性潜力,但对母亲行为和后代神经发育的影响尚不清楚.
研究的目的:
- 调查发育期GBH暴露对幼犬抗氧化系统,焦虑,社交互动和认知/感官运动功能的影响.
- 评估对母亲行为的影响.
主要方法:
- 幼通过母乳每天接触到25或50毫克/升的GBH.
- 对大脑抗氧化酶和脂质过氧化的生物化学分析.
- 乙胆酶 (AChE) 活动测量.
- 行为测试包括开放场,Y迷宫,物体识别,社交互动和神经发育测试 (伸直反射,负地质测试).
主要成果:
- 暴露于GBH对抗氧化酶产生了负面影响,并在幼犬大脑中增加了脂质过氧化.
- 观察到大脑ACHE特定活性显著下降.
- 接受治疗的后代表现出焦虑,记忆和社交能力缺陷.
- 发现了感觉运动障碍和异常的母亲行为.
结论:
- 发育中的大脑对GBH暴露非常敏感.
- 发育性暴露于GBH导致后代显著的神经发育和行为缺陷.
- GBH对母亲的行为和后代的神经发育构成风险.
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