肺器官:对最近进展的系统审查及其未来前景
T Thangam1, Krupakar Parthasarathy2, K Supraja3
1Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, 600119, India.
Tissue engineering and regenerative medicine
|March 11, 2024
概括
肺部有机体,人体肺部的实验室培养模型,为研究呼吸系统疾病和加速药物发现提供了先进的工具. 这些模型弥合了动物试验和人体试验之间的差距,降低了成本和时间.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 翻译研究是翻译研究.
背景情况:
- 器官体是体外3D组织模型,复制人类器官结构和生理学.
- 目前的应用包括基础研究,分子医学和制药药物测试.
- 肺部有机体特别模拟肺部病理生理学和疾病.
研究的目的:
- 系统地审查肺器官的发展情况.
- 探索它们的潜在祖先和在翻译研究中的应用.
- 讨论建立疾病研究和再生的肺器官的方法.
主要方法:
- 系统审查现有的关于肺器官发育的文献.
- 分析建立各种肺器官模型的方法.
- 在疾病建模和药物查中评估肺器官应用.
主要成果:
- 肺部有机体对于了解细胞相互作用,组织生物学和再生非常有价值.
- 它们提供了对不同阶段疾病病原体的洞察.
- 肺部有机体有助于研究肺部病理生理学和疾病进展.
结论:
- 肺部有机体对于在药物发现中弥合动物模型和人类临床试验之间的差距至关重要.
- 它们为研究呼吸系统疾病及其病理生理学提供了一种新型模型.
- 肺部有机体,结合生物工程,将推进呼吸系统疾病研究和药物查.
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