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Miguel Morales-Navas¹, Cristian Perez-Fernandez¹, Sergio Castaño-Castaño^1,2

¹Department of Psychology and Health Research Center (CEINSA), University of Almería, Ctra. Sacramento, s/n, 04120, Almería, Spain.

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概括

在大鼠中,产前暴露于有机酸盐农药酸 (CPF) 可能会影响社会行为,类似于自闭症模型的酸 (VPA). 暴露于CPF的老鼠在青春期表现出改变的社会新奇反应,在成年后恢复.

科学领域:

神经科学是一个神经科学.
毒理学毒理学毒理学
发展生物学发展生物学

背景情况:

有机酸盐农药,如酸 (CPF),正在越来越多地研究与自闭症谱系障碍 (ASD) 的潜在联系.
怀孕期间给予瓦尔酸 (VPA) 是创建自闭症动物模型的一种成熟方法.

研究的目的:

调查Wistar大鼠中产前暴露于pyrifos (CPF) 是否会诱导与酸 (VPA) 诱导的自闭症模型中观察到的行为表型相似的行为表型.
评估产前CPF暴露对青少年和成年大鼠社交能力和社会新性的影响.

主要方法:

在特定的妊娠日 (GD 12.5-15.5) 期间,Wistar大鼠在产前暴露于pyrifos (CPF,1 mg/kg) 或酸 (VPA,400 mg/kg).
三室社会互动测试被用来评估社交能力和对社会新奇事物的反应在两个实验阶段:青春期和成年期.
来自CPF和VPA暴露组的行为数据与对照组 (CNT) 相比较.

主要成果:

与对照组相比,在产前暴露于CPF或VPA的动物表现出明显的行为表型.
在青春期,暴露于CPF的老鼠表现出对社会新奇事物反应的负指数,这种模式也在暴露于VPA的老鼠中观察到,尽管不那么明显.
在CPF和VPA实验组中,在成年期对社会新奇事物的反应得到了恢复.

结论:

在大鼠中,产前暴露于pyrifos (CPF) 可以诱导社会互动的行为变化,特别是关于社会新奇的行为.
在暴露于CPF的老鼠中观察到的行为效应与已建立的酸 (VPA) 自闭症谱系障碍动物模型有相似之处.
这些发现表明,产前有机类农药暴露在改变与自闭症相关的社会行为方面可能发挥作用.

关键词:

自闭症自闭症自闭症基基酸盐 (Chlorpyrifos) 是一种酸盐.杀虫剂是一种杀虫剂.社交性社交性瓦尔酸是一种酸.

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