在儿童和青少年中脱发区域的治疗选择
Linnea L Westerkam1, Diana B McShane2, Elizabeth L Nieman2
1School of Medicine, University of North Carolina, Chapel Hill, NC, USA. linnea_westerkam@med.unc.edu.
Paediatric drugs
|March 11, 2024
概括
小儿脱发区治疗的有效性各不相同,对儿童批准的选择有限. 本综述详细介绍了当前和新兴疗法,强调需要更多的临床数据来改善这种疾病的儿科护理.
科学领域:
- 皮肤病学 皮肤病学
- 儿科医学 儿科医学
- 药理学 药理学 是一个学科.
背景情况:
- 大发性脱发症 (AA) 影响大约2%的人口,通常从童年开始.
- 目前,只有Ritlecitinib被FDA批准用于12岁及以上的患有AA的儿科患者.
- 对于患有AA的年幼儿童,存在着大量尚未满足的有效和批准的治疗需求.
研究的目的:
- 审查现有和新兴的治疗选择,用于儿科脱发.
- 总结针对AA儿童的局部,注射和口服疗法.
- 为儿童AA提供药物开发管道和正在进行的临床试验的概述.
主要方法:
- 进行了一项全面的PubMed搜索,使用与大发性脱毛症及其治疗相关的术语.
- 纳入标准仅关注涉及儿科患者的研究.
- 该审查包括常用的,新的和不太频繁的治疗方式.
主要成果:
- 常见的治疗方法包括皮质类固醇,甲醇和米诺克西迪尔.
- 简氏激酶 (JAK) 抑制剂代表了一类新的有前途的治疗方法.
- 在不同治疗方法中观察到可变的疗效,往往需要组合治疗.
结论:
- 目前儿科大发性脱毛症的治疗环境有限,有效性可变.
- 对于儿科AA患者的最佳结果,可能需要组合治疗.
- 进一步的强有力的临床数据是提高儿科脱毛率的管理必不可少的.
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