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Updated: Jul 1, 2025

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

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脊柱1H,13C和15N为人类SERF2的化学转移分配

Bikash R Sahoo1,2, Vivekanandan Subramanian3, James C A Bardwell4,5

  • 1Howard Hughes Medical Institute, Chevy Chase, MD-20815, USA. bsahoo@umich.edu.

Biomolecular NMR assignments
|March 11, 2024
PubMed
概括

人类的小EDRK丰富因子蛋白SERF2驱动与神经退行性疾病相关的粉样蛋白形成. 这项研究为SERF2提供了关键的结构洞察力,揭示了它与α-Synuclein的相互作用以及在帕金森病的发病过程中的潜在作用.

关键词:
粉样蛋白是什么 粉样蛋白是什么这就是NMR的NMR.增强了对磁性放松,增强了对磁性放松.服务 (SERF) 是一个服务器.α-Synuclein 是一种蛋白质.

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The position of the absorption signal of a sample is reported relative to the position of the signal of tetramethylsilane (TMS), which is added as an internal reference while recording spectra. The difference between the absorption frequencies of the sample and TMS (in Hz) is divided by the spectrometer operating frequency (in MHz) to obtain a dimensionless quantity called the chemical shift. It is reported on the δ (delta) scale and expressed in parts per million.
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Absorption signals of all the protium nuclei...
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Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
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Protons in identical electronic environments within a molecule are chemically equivalent and have the same chemical shift. The replacement test is a useful tool to identify chemical equivalence and predict NMR spectra. A substituent replaces each of the protons being examined and the resulting molecules are compared. If the same molecule is obtained, the protons are equivalent or homotopic. Replacement of any hydrogens in ethane by chlorine yields chloroethane because all six protons are...
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