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与严重抑郁症相关的人文和经济负担:回顾性横截面分析
Larry Culpepper1, Ashley Martin2, Nadia Nabulsi3
1Department of Family Medicine, Boston University School of Medicine, 90 Sylvia Ln, Westport, MA, 02790-1406, USA. laculpep@bu.edu.
大型抑郁症 (MDD) 显著影响生活质量,增加医疗保健费用. 较高的MDD严重程度与更糟糕的结果和更大的资源利用相关,突出了该疾病的实质性负担.
科学领域:
- 卫生经济学 卫生经济学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 重度抑郁症 (MDD) 是一个重要的全球健康问题.
- 多次性疾病导致大量的经济成本和与健康相关的生活质量 (HRQoL) 的降低.
- 了解跨不同MDD严重程度的负担对于资源分配和治疗策略至关重要.
研究的目的:
- 描述HRQoL,医疗保健资源利用率 (HCRU) 和与MDD患者相比没有MDD患者的相关成本.
- 分析这些结果,跨越不同程度的MDD严重程度.
- 检查先前药物治疗失败对MDD患者结果的影响.
主要方法:
- 利用了2019年国家健康和健康调查的数据.
- 确定了患有MDD的成年参与者,按严重程度分层 (最小/轻度,中度,中度严重,严重),以及没有MDD的对照组.
- 使用SF-36v2和EQ-5DVAS评估HRQoL,HCRU (住院治疗,急救访问,医疗专家访问),以及直接/间接成本. 采用了双变量和多变量分析.
主要成果:
- 患有MDD的患者的HRQoL显著低于对照组 (P < 0.001).
- 增加MDD的严重程度与HRQoL的下降,医疗保健提供者和ED访问的增加,以及更高的直接和间接成本有关.
- 对于MDD患者来说,总成本明显高 (8814美元直接,5425美元间接),而不是对照组 (6072美元直接,3085美元间接).
结论:
- 长期抑郁症给患者带来了巨大的负担,其特点是减少HRQoL和增加医疗保健利用率和成本.
- 经济和生活质量的影响随着MDD的严重程度而升级.
- 在MDD中,先前的药物治疗失败进一步加剧了这些负担,特别是间接成本.
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