为了更好地了解帕金森病患者的预期性姿势调整
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Jana Seuthe1,2, Anna Heinzel2, Femke Hulzinga3
1Institute of Interdisciplinary Exercise Science and Sports Medicine, MSH Medical School Hamburg, Hamburg, Germany.
PloS one
|March 11, 2024
概括
帕金森病中的预期性姿势调整 (APA) 与双重任务步态有关,但与结无关. 训练改善了步态,但增加APA大小可能不是最好的干预目标.
科学领域:
- 神经科学是一个神经科学.
- 生物力学 生物力学
- 康复 康复 康复 康复
背景情况:
- 预期姿势调整 (APA) 对于稳定的运动至关重要,但在帕金森病 (PD) 中经常受到损害.
- 在PD中,APAs与步行启动,进展和步行结 (FOG) 之间的具体关系仍然不完全理解.
- 研究动态姿势控制训练对APA和相关步行参数的影响对于有效的康复策略至关重要.
研究的目的:
- 检查帕金森病 (PD) 患者预期性姿势调整 (APA) 和步行启动,步行和步行结 (FOG) 之间的关联.
- 评估动态姿势控制具有挑战性的培训计划对这些特征的影响.
- 为了确定基线APA特征是否预测步行表现和训练诱导的改进.
主要方法:
- 用可穿戴传感器和移动捕捉来评估步行启动和行走.
- 用可穿戴传感器测量转身和FOG结果,在跑步机训练干预之前,之后立即,并在跑步机训练干预后4周.
- 统计分析包括培训效应的混合模型和APA和步态结果之间的相关性分析.
主要成果:
- 在双重任务 (DT) 条件下基线中位侧面APA大小与DT步伐速度和步伐长度正相关.
- 训练干预导致了第一步运动范围的最大改善,这对两种训练类型都有类似的影响.
- 训练后,中侧APA尺寸与第一步运动范围相关,仅在DT条件下的非冷器中.
结论:
- 在DT期间的基线APA与PD中的DT步态特征有关,但与第一步参数或FOG无关.
- 在非冷器中,培训引起的APA变化与第一步运动范围的改善有关,仅在非冷器中.
- 针对APA大小增大可能不是改善PD患者整体运动的最佳策略.
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