雾化和体上空气道沉积的脂质体载体系统的上空气道沉积
Ondrej Mišík1, Jana Kejíková2, Ondřej Cejpek1
1Department of Thermodynamics and Environmental Engineering, Faculty of Mechanical Engineering, Brno University of Technology, Technicka 2896/2, 616 69 Brno, Czech Republic.
Molecular pharmaceutics
|March 11, 2024
概括
这项研究评估了用于雾化剂治疗的脂质体系统,发现DPPC-PA-Chol与Pari LC Sprint Star雾化剂在稳定性和颗粒大小方面是最佳的,这表明肺部药物输送的潜力.
科学领域:
- 制药和药物输送 制药和药物输送
- 呼吸系统医学 呼吸系统医学
- 生物技术是生物技术.
背景情况:
- 脂质体载体系统为肺部药物输送提供了一个有希望的途径.
- 为化优化脂质体配方,需要仔细考虑稳定性和气溶特性.
- 了解雾化器类型和呼吸模式的影响对于有效的肺部沉积至关重要.
研究的目的:
- 为了在不同的雾化器中比较两个脂质体系统 (DPPC-PA-Chol和DPPC-PEG-Chol) 的稳定性和气溶特性.
- 评估雾化剂选择,流量和呼吸形状对脂质体气溶特性的影响.
- 通过使用现实的气道模型,评估最佳脂肪体系统的*in vitro*肺沉积.
主要方法:
- 在使用空气喷射,振动网和超声波雾化器进行原子化时评估脂质体稳定性.
- 产生的气溶的空气动力学颗粒大小分布分析.
- 使用安德森级联冲击器和现实的上呼吸道复制品进行的"体外"沉积研究.
主要成果:
- 由酸和胆固醇 (DPPC-PA-Chol) 系统与Pari LC Sprint Star雾化器稳定下来的二甲基酸酸胆固醇显示出卓越的稳定性和颗粒大小.
- 灵感流速适度影响颗粒大小,较高的流速降低颗粒大小.
- 大约90%和70%的气溶在静止流和现实的呼吸形状下分别透到气管之外.
结论:
- 由Pari LC Sprint Star雾化DPPC-PA-Chol是一种适合用于肺部药物输送的组合.
- 现实的实验室沉积研究,考虑到气道几何和呼吸模式,提供比传统方法更准确的见解.
- 脂质体载体系统显示出基于雾化剂的肺药物递送的显著潜力,尽管预计沉积的患者特异性变化.
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