通过直肠超声波引导的前列腺活检后感染相关并发症的微生物学
Cynthia T Nguyen1, Alison Lew1, Natasha N Pettit1
1Department of Pharmacy, University of Chicago Medicine, Chicago, IL, United States.
概括
跨直肠前列腺活检显示24小时抗生素预防的感染率较低. 使用西普洛素和先前的细菌性尿是影响前列腺活检后感染并发症的关键因素.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 感染性并发症是跨直肠前列腺活检后的一个担忧.
- 了解发病率,微生物学和风险因素对于患者安全至关重要.
研究的目的:
- 为了确定跨直肠前列腺活检后感染性并发症的发病率,微生物学和风险因素.
- 评估当前抗生素预防方案的有效性.
主要方法:
- 对1471名接受过直肠前列腺活检的患者进行了回顾性队列研究.
- 抗生素预防包括塞法莱克辛和西普罗夫洛克萨,使西普罗夫洛克萨的持续时间从48小时减少到24小时.
- 主要结局:感染相关并发症的发生率 (30天内UTI或细菌血).
主要成果:
- 感染相关并发症的总发病率为1.6% (24/1471).
- 发生了四例大肠杆菌病的病例,所有病例都发生在接受抗生素预防的患者中.
- 使用西普罗夫洛克萨与并发症风险降低有关 (OR 0.20),而之前的细菌性尿风险增加 (OR 4.77).
- 与抗生素相关的不良事件发生在0.3%的患者中.
结论:
- 在24小时内服用西普罗夫洛克萨和塞法莱克辛,感染并发症和不良事件的发生率较低.
- 没有使用手术前的直肠查.
- 对程序和宿主因素的进一步研究可能有助于尽量减少并发症.
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