在初级保健数据库中,类风湿性关节炎的突发症状:根据种族和社会经济地位的变化
Alexander d'Elia1, Aliaksandra Baranskaya2, Shamil Haroon3
1Department of Public Health Policy and Systems, Institute of Population Health, University of Liverpool, Liverpool, UK.
Rheumatology (Oxford, England)
|March 11, 2024
概括
类风湿性关节炎 (RA) 的前兆症状因种族和社会经济地位而异. 这些差异对于公平的临床实践和公正的预测工具至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 类风湿性关节炎 (RA) 诊断依赖于识别早期症状.
- 跨人口群体症状呈现的变化可能会影响及时诊断和治疗.
- 常规收集的医疗保健数据提供了对人口层面症状模式的洞察.
研究的目的:
- 调查RA的前期症状是否因种族和社会经济地位而有所不同.
- 分析RA诊断之前的初级保健记录中的症状编码.
主要方法:
- 使用临床实践研究数据链接Aurum (CPRD) 数据库 (2004-2022) 的横截面研究.
- 包括RA诊断代码的成年人;分析的症状编码在前24个月.
- 经性别,年龄,BMI和吸烟状况调整后的后勤回归,比较白人种族和最高社会经济五分之一.
主要成果:
- 分析了70,115例RA病例;发现了21种常见症状.
- 南亚种族与较高的肌肉和肩部疼痛的几率有关.
- 黑人种族与意外减肥和脚疼痛的患病率增加有关.
- 较低的社会经济地位与更高的早晨硬和跌倒的编码相关.
结论:
- 在种族和社会经济群体之间对RA前期症状的编码存在显著差异.
- 意识到这些差异对于改善不同人群的临床护理至关重要.
- 解决这些变异可以帮助减轻RA预测模型中的算法偏差.
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
86
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
86
Surveys
14.8K
Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
14.8K
The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
Stereotypes, Prejudice, and Discrimination
90.2K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
90.2K
Autoimmune Disorders
434
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
434


