酒精消费调查问卷:在墨西哥裔美国年轻成年人样本中的规模发展和与ADH7的关联
Cindy L Ehlers1, Libo Li2, Qian Peng1
1Scripps Research Institute, United States.
Alcohol (Fayetteville, N.Y.)
|March 11, 2024
概括
酒精消费问卷 (ACQ) 有效地衡量了酒精使用障碍 (AUD) 的风险. 它显示出与AUD严重程度和保护性ADH7基因变异在墨西哥裔美国年轻成年人的强有力的联系.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 酒精使用障碍 (AUD) 是一个重要的公共卫生问题.
- 了解引发大量饮酒的因素对于AUD预防和治疗至关重要.
- 现有的酒精渴望和克制度的尺度为新措施的开发提供了信息.
研究的目的:
- 引入和验证用于评估酒精消费模式的酒精消费问卷 (ACQ).
- 在墨西哥裔美国年轻成年人中探索ACQ,AUD和遗传因素之间的关系.
主要方法:
- 一个由699名墨西哥裔美国年轻人组成的样本完成了ACQ.
- 用因子分析和物品响应理论 (IRT) 来进行尺度提炼.
- 后勤回归分析了与AUD和ADH7基因变异的关联.
主要成果:
- 该ACQ被减少到14项,产生可靠的整体,消费和享受分数 (Cronbach的alpha:0.896,0.896,0.780).
- 观察到高的测试-重新测试可靠性 (0.80-0.98).
- ACQ分数与AUD严重程度和家族病史有很强的相关性,对保护性ADH7变体有显著的关联.
结论:
- 该ACQ是酒精消费的有效和可靠的衡量标准.
- 在研究的人群中,ACQ显示了与AUD和ADH7基因变异的显著关联.
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