在内镜下粘膜剖析后使用自组合凝预防食道狭窄:美国多中心前性研究 (附视频)
Dennis Yang1, Muhammad K Hasan1, Yasi Xiao1
1Center for Interventional Endoscopy, AdventHealth, Orlando, Florida, USA.
Gastrointestinal endoscopy
|March 11, 2024
概括
自组合凝 (SAP) 凝在内镜下粘膜解剖 (ESD) 后预防食道狭窄方面表现有前途. 这项研究发现,SAP凝的应用是有效和简单的,ESD患者的收缩率很低.
科学领域:
- 胃肠病学 胃肠病学
- 手术创新 在外科创新.
- 生物材料是一种生物材料.
背景情况:
- 手术后食道狭窄是广泛的内镜下粘膜剖析 (ESD) 后的常见并发症.
- 自组合凝 (SAP) 凝在促进组织愈合和重新上皮化方面表现出潜力.
- 目前用于ESD后食道收缩的预防方法需要进一步评估.
研究的目的:
- 评估自组合 (SAP) 凝在内镜下粘膜解剖 (ESD) 后预防食道狭窄的疗效.
- 评估SAP凝在临床环境中的安全性和易用性.
主要方法:
- 一项多中心前性研究,涉及43名接受食道ESD并随后应用SAP凝的患者.
- 纳入标准:ESD粘膜缺陷涉及食道周长≥50%;高风险病例定义为≥75%的周长.
- 狭窄的定义:无法通过8.9毫米内镜或症状的窄口径光线.
主要成果:
- 在所有情况下,SAP凝成功地被应用,应用时间中位数为4分钟.
- 整体收缩率为20.9% (9/43);高风险病例的收缩率为30.8%.
- 所有狭窄症都通过内镜治疗得到解决;6.9%的患者经历了可控的术后出血.
结论:
- 应用SAP凝是一种可行的,快速和有效的方法,用于预防ESD后食道狭窄.
- 观察到的收缩率与现有的预防策略相当.
- 需要进一步的比较研究来证实这些发现.
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