在 rs2274333 的 gustin 基因变异和 PROP 品尝者状态影响饮食脂肪的感知:一个逐步的多重回归模型研究研究
Gowtham Subramanian1, Vinithra Ponnusamy1, Keerthana Vasanthakumar1
1Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore - 641046, Tamil Nadu, India.
The Journal of nutritional biochemistry
|March 11, 2024
概括
格斯基因 (CA-VI) rs2274333的多态性影响了6-n-propylthiouracil (PROP) 的品味能力和身体质量指数 (BMI). 这种遗传变异影响了饮食中的脂肪感知和真菌状乳头密度.
科学领域:
- 遗传学 是一个遗传学.
- 人体生理学 人体生理学
- 营养科学 营养科学
背景情况:
- 格斯 (碳酸无水素VI - CA-VI) 是味蕾发育的营养因子.
- 在CA-VI基因中的多态性,特别是rs2274333,与6-n-propylthiouracil (PROP) 味觉和真菌状乳头 (FP) 密度有关.
- PROP品尝者身份影响饮食脂肪感知和身体组成,但 gustin基因型,脂肪感知,PROP品尝和BMI之间的关系需要进一步调查.
研究的目的:
- 研究CA-VI基因多态性 (rs2274333) 与对脂肪和苦味的味觉敏感性之间的关联.
- 评估古斯基因型对6-n-propylthiouracil (PROP) 味觉能力,真菌状乳头 (FP) 密度和体重指数 (BMI) 的影响.
- 为了确定PROP品尝者状态和CA-VI基因型如何影响饮食脂肪感知.
主要方法:
- 对178名健康个体的脂肪和苦味的味觉敏感性被评估,使用了一般标记的大小尺度和替代强制选择方法.
- 使用食品染料染色技术量化真菌状乳头 (FP) 密度.
- 该CA-VI基因多态性 (rs2274333) 通过限制片段长度多态性 (RFLP) 进行了基因定型.
主要成果:
- 在CA-VI基因型/等位基因频率,PROP测试者状态和BMI (p<0.001) 之间发现了显著的相关性.
- 与其他群体相比,具有AA基因型和PROP超级品尝者身份的个体对酸 (LA) 具有增强的味觉敏感性和更高的FP密度.
- 体重指数和PROP测试者状态是LA感知能力的显著预测因素,而PROP测试者状态和CA-VI基因型解释了LA超值强度变化的73.3%.
结论:
- 在rs2274333的CA-VI基因突变与味蕾环境有关,影响对食脂肪和苦味的味觉偏好.
- 这种遗传变异既影响了对PROP等苦味化合物的感知,也影响了对食脂肪的敏感性.
- 研究结果强调了遗传因素,口腔感官感知和BMI等生理特征之间的相互作用.
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