儿童的鼻微生物群与严重的喘恶化有关
Gina J van Beveren1, Wouter A A de Steenhuijsen Piters2, Shelley A Boeschoten3
1Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Department of Paediatrics, Spaarne Hospital, Haarlem, The Netherlands.
患有严重喘恶化症的儿童具有明显的鼻微生物组,其中葡萄球菌和口腔细菌增加,有益的微生物减少. 这些变化可能与环境暴露有关.
科学领域:
- 微生物学 微生物学
- 肺部病理学 肺部病理学
- 环境健康 环境健康
背景情况:
- 呼吸道微生物组在喘的发展和进展中起着重要作用.
- 了解儿科喘恶化中的鼻微生物群至关重要.
研究的目的:
- 为了研究患有严重喘恶化症的儿童的鼻菌群组成.
- 探索微生物群与药物使用,空气质量和病毒感染之间的联系.
主要方法:
- 一项涉及2-18岁儿童的横截面研究,这些儿童因喘恶化而入院 (n=162).
- 病例对照分析将喘恶化儿童与健康对照进行了匹配 (n=87与n=182).
- 使用16S-rRNA基因测序来表征鼻微生物群.
主要成果:
- 与对照组相比,患有喘恶化的儿童表现出更高的微生物多样性和独特的社区组成.
- 在一些病例中,观察到葡萄球菌和"口腔"种群 (尼塞里亚,韦龙氏菌,链球菌) 的丰度增加,以及Dolosigranulum pigrum,Corynebacterium和Moraxella的丰度减少.
- 尼塞利亚的丰富程度与疾病的严重程度和细颗粒物暴露相关; 血球菌和链球菌与吸入性皮质类固醇使用相关. 没有发现病毒感染的相关性.
结论:
- 儿童喘恶化与葡萄球菌和"口腔"微生物的过度生长有关,以及有益的共生菌的不足.
- 环境和医疗暴露可能会影响这些微生物变化,但需要进一步调查因果关系.
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