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hOGG1:一种新型的调解剂,用于尼托胺诱导的食道瘤发生

De-Rong Tang¹, Cheng-Lin Li¹, Zhi-Yun Xu¹

¹Department of Thoracic Surgery, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|March 11, 2024

概括

低的人类8-Oxoguanine DNA Glycosylase (hOGG1) 表达可能会增加食道癌症的风险,特别是当暴露于环境污染物如尼托胺时. hOGG1可能会调解氨酸诱导的食道瘤发生.

科学领域:

遗传学和分子生物学
环境健康环境健康
在瘤学瘤学.

背景情况:

人类8-Oxoguanine DNA Glycosylase (hOGG1) 在食道状细胞癌 (ESCC) 发展中的作用,特别是关于环境因素,尚未完全理解.
研究hOGG1在ESCC中的表达对于了解其与环境风险因素的潜在相互作用至关重要.

研究的目的:

为了确定ESCC组织中的hOGG1表达水平.
探索hOGG1与环境风险因素,特别是胺胺,在ESCC病变发生过程中的相互作用.

主要方法:

在高和低ESCC流行地区的人群中,用气色谱-质谱法 (GC-MS) 测量了尿中的尼托拉胺水平.
在食道组织中分析了hOGG1基因表达,以评估其与尼托胺暴露的相互作用.

主要成果:

食道状细胞癌 (ESCC) 患者呈现显著增加的尼托拉胺水平和降低的hOGG1 mRNA表达.
在ESCC中,在降低的hOGG1mRNA水平和非自来水消耗之间观察到显著的相互作用.
hOGG1调解了N-尼托甲基胺 (NMEA) 和ESCC之间的关系的33.4%.

结论:

低hOGG1表达,再加上接触N-二甲基胺 (NDMA) 等环境污染物,可能导致特定人群的食道癌发病率高.
hOGG1成为尼托胺诱导的食道癌发展的潜在调解者.

关键词:

8 - 氧古氨酸 DNA 糖化酶.只有案例研究的研究.食道癌是食道癌的一个类型.基因表达基因表达基因表达基因与环境的相互作用.N-尼胺氨基化合物的含量

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