BDE-99刺激了异常棕色/色脂肪细胞的产生
Qing Wen1, Xinni Xie2, Qidong Ren2
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100190, China; Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
像BDE-99这样的制阻燃剂促进棕色/色脂肪细胞的发展,但会损害它们的能量代谢和内分泌功能,这表明它们在肥胖和代谢障碍中起着作用.
科学领域:
- 环境毒理学环境毒理学
- 代谢研究的研究.
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 制阻燃剂 (BFRs) 在脂肪组织中积累.
- BFRs对热生成的棕色/色脂肪细胞的影响尚不清楚.
- BDE-99是人类中普遍存在的一种多化二乙烯 (PBDE).
研究的目的:
- 研究BDE-99对棕色/色脂肪细胞分化和功能的影响.
- 评估BDE-99的潜在肥胖和代谢破坏性影响.
主要方法:
- 在分化过程中C3H10T1/2MSC暴露于BDE-99的情况.
- 评估棕色/色脂肪细胞标记物 (UCP1,Cidea) 和线粒体功能.
- 线粒体和阿迪波金分泌的脂质组分析.
主要成果:
- 暴露于BDE-99促进了棕色/色脂肪细胞的分化,增加了UCP1和线粒体潜力.
- 线粒体最大呼吸和备用呼吸能力被BDE-99降低.
- 用BDE-99治疗的脂肪细胞显示了线粒体脂质样本的改变和抵抗素分泌的增加.
结论:
- 暴露于BDE-99会诱导棕色/色脂肪细胞中的异常能量代谢和内分泌功能.
- 累积的BDE-99可能会干扰脂肪细胞功能,导致肥胖和代谢障碍.
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