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长非编码RNA在胸腔和腹腔大动脉动脉瘤的发展中的病原学意义
Aksana N Kucher1, Iuliia A Koroleva1, Maria S Nazarenko2
1Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, 634050, Russia.
Biochemistry. Biokhimiia
|March 11, 2024
概括
长非编码RNAs (lncRNAs) 在大动脉动脉瘤 (AA) 的发展中发挥着关键作用. 在lncRNA表达的变化及其参与竞争的内源RNA网络是了解AA病原学的关键.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 心血管研究研究心血管研究
背景情况:
- 大动脉动脉瘤 (AA) 是一种严重的疾病,具有显著的流行率和并发症风险.
- 了解AA背后的分子机制对于开发有效的治疗方法至关重要.
研究的目的:
- 审查和综合目前关于长非编码RNAs (lncRNAs) 在大动脉动脉瘤病变发生中的作用的数据.
- 探索lncRNAs在各种AA位置及其监管网络中的参与.
主要方法:
- 在AA中对lncRNA的实验和生物信息学研究的文献综述.
- 在受影响的大动脉组织中分析基因表达数据 (lncRNA,mRNA,microRNA).
- 识别竞争的内源RNA (ceRNA) 网络,其中涉及 lncRNAs.
主要成果:
- lncRNAs涉及至关重要的代谢途径和AA的病原机制,无论位置 (胸部或腹部).
- 在AA发育过程中观察到lncRNA,mRNA和microRNA表达的持续变化.
- lncRNAs在ceRNA网络中起作用,调节多种细胞和生化事件,在腹部和胸部AA方面确定了不同的网络.
- lncRNA相互作用,包括表观遗传过程,以及与临床/生化参数的相关性,都与AA病变发生有关.
结论:
- lncRNAs是AA发展的重要调节者,通过复杂的ceRNA网络起作用.
- 了解lncRNA的作用为早期AA诊断和新的治疗策略提供了基础.
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