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基于酸盐的NeoPUTTY水泥的生物兼容性和生物活性潜力:在老鼠身上进行的一项体内研究

Evelin Carine Alves Silva¹, Jéssica Arielli Pradelli¹, Guilherme Ferreira da Silva²

¹Department of Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil.

International endodontic journal

|March 11, 2024

概括

新的牙科修复材料NeoPUTTY显示出更大的炎症反应,但也诱导了矿化,表明生物相容性. 它的炎症反应随着时间的推移而减少,这表明它适合于牙科应用.

科学领域:

生物材料科学生物材料科学
牙科材料牙科材料
组织工程是组织工程.

背景情况:

牙纸封闭和根修复需要生物相容的材料.
评估新生物陶的炎症反应和矿化潜力对于临床应用至关重要.

研究的目的:

为了比较NeoPUTTY (NPutty) 与Bio-C Repair (BC) 和MTA Repair HP (MTA HP) 的炎症反应和矿化诱导.

主要方法:

在大鼠体内进行皮下植入材料的时间为7,15,30和60天.
对囊厚度,炎症细胞 (ICs),纤维细胞,原蛋白和骨素 (OCN) 表达的组织学分析.
使用ANOVA和非参数试验进行统计分析.

主要成果:

所有材料都引起了炎症,NPutty最初显示出更高的ICs.
所有组的炎症反应和囊厚度随着时间的推移而下降.
NPutty显示出显著的矿化潜力,与BC和MTAHP相比60天.

结论:

尽管最初的炎症反应,NeoPUTTY表现出生物相容性和矿化能力.
材料的炎症特征随着时间的推移而改善,支持其在牙科修复中的使用.
NeoPUTTY是一种有前途的生物陶,用于需要矿化诱导的牙科应用.

关键词:

生物陶生物陶是一种酸酸是一种酸盐.炎症反应是一种炎症反应.

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