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Updated: Jul 1, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Published on: February 21, 2018

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USP22通过PML-RARα稳定和IFN抑制来调节APL的分化

Lisa Kowald1, Jens Roedig1, Rebekka Karlowitz1

  • 1Institute for Experimental Pediatric Hematology and Oncology, Medical Faculty, Goethe-University Frankfurt, Komturstrasse 3a, 60528, Frankfurt am Main, Germany.

Cell death discovery
|March 12, 2024
PubMed
概括

乌比基特异性酶22 (USP22) 调节急性肌细胞白血病 (APL) 蛋白质稳定性和干扰素信号传递. 失去USP22会增加APL中ATRA介导的分化灵敏度.

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