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Updated: Jul 1, 2025

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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在哺乳动物细胞中进行dCas13介导的转化抑制,以实现精确的基因沉默

Antonios Apostolopoulos1,2, Naohiro Kawamoto2, Siu Yu A Chow3

  • 1Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8561, Japan.

Nature communications
|March 12, 2024
PubMed
概括

研究人员开发了CRISPRδ,这是一种新型的基因沉默方法,可以在不降解mRNA的情况下阻止翻译. 这种高度特定的方法为RNA干扰和CRISPR-Cas13系统提供了一个精确的基因淘汰替代方案.

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