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Updated: Jul 1, 2025

Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics
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使用数据独立获取方法自动化用于/交换质谱的数据分析

Frantisek Filandr1, Vladimir Sarpe1, Shaunak Raval1,2

  • 1Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, T2N 4N1, Canada.

Nature communications
|March 12, 2024
PubMed
概括

我们开发了一种新的/交换方法 (HX-MS2),用于更快,更准确的蛋白质分析. 这种技术提高了数据的可靠性,加快了复杂样本的表征,使得蛋白质组学中的应用更广泛.

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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
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