早期流感A (H1N1) 感染独立编程大脑连接,HPA AXIS和组织特异性基因表达特征
Myriam P Merz1,2,3, Snehaa V Seal1,2, Nathalie Grova1,4
1Immune Endocrine and Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), 29 Rue Henri Koch, 4354, Esch-Sur-Alzette, Luxembourg.
Scientific reports
|March 12, 2024
概括
在小鼠中感染的流感会对生长,新陈代谢和大脑连接产生持久的性别特异性影响,即使在感染消失后也是如此. 这些变化是独立于免疫系统反应发生的.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 生命早期的逆境,包括病毒感染,可能导致长期的健康问题.
- 生命早期的急性病毒感染与免疫系统之外的非目标效应有关,例如变化的下丘脑-垂体-上腺 (HPA) 轴功能和新陈代谢.
研究的目的:
- 在小鼠模型中研究早期流感A (H1N1) 感染对HPA轴调节,能量代谢和大脑连接的长期影响.
- 为了确定这些影响是否在感染消失后还存在,以及它们是否与性别有关.
主要方法:
- 使用了一种患有出生后第14天 (PND 14) 流感A (H1N1) 感染的小鼠模型.
- 采用了表型测量,基因表达阵列和扩散神经成像 (大脑MRI).
- 分析了HPA轴的功能,能量代谢 (血糖,皮质) 和大脑连接在PND56时.
主要成果:
- 解决的H1N1感染显示出性别特异性影响,包括男性的增长迟缓和PND 42的基线葡萄糖和皮质激素水平的改变.
- 大脑MRI显示皮质,中脑和小脑的连接性减少.
- 组织特异性基因表达特征伴随着连接性变化,在组织之间很少有共同的途径.
- 观察到对不同系统的独立影响,不论是HPA轴或免疫干扰.
结论:
- 一种感染可以诱导持续的,性别特异的神经发育和代谢变化.
- 已解决的病毒感染可以对大脑连接和生理学产生长期的"脱而出"影响.
- 这些发现突显出发育系统对生命早期压力因素的脆弱性,独立于直接的免疫参与.
关键词:
皮质类固醇胺的皮质.早期生活中的逆境.葡萄糖的产生和生成.这是H1N1流感.在HPA轴上.感染 感染 感染流感是一次流感.这就是为什么MRI是MRI.多机构编程多机构编程压力 压力 压力 压力更多相关视频
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