肺静脉对左心房流动模式和血栓形成的作用
Jordi Mill1, Josquin Harrison2, Marta Saiz-Vivo3
1Physense, BCN Medtech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, 08018, Barcelona, Spain. jordi.mill@upf.edu.
Scientific reports
|March 12, 2024
概括
肺静脉的角度和对齐显著影响左心房附属体的血液流动和心房动患者的血栓形成风险. 这项研究分析了130个患者特异型模型,以确定凝块发育的关键因素.
科学领域:
- 心血管研究研究心血管研究
- 医疗成像医学成像
- 计算流体动力学的流体动力学.
背景情况:
- 心房动 (AF) 是一种常见的心律失常,与左心房附属体 (LAA) 中的血栓形成有关.
- 由于数据采集的挑战,肺静脉 (PV) 解剖学对LAA血液动力学和血栓形成的影响仍然不清楚.
- 现有的in-silico研究范围和患者数量有限.
研究的目的:
- 为了研究光伏配置和方向对左心房 (LA) 血流模式的影响.
- 为了确定LA血动力学,LAA形态和血栓形成风险之间的关系.
- 建立最大的LA流体动力学模拟患者特定队列.
主要方法:
- 在130个患者特定的LA模型上进行计算流体动力学 (CFD) 模拟.
- 对光伏角度,数量,LAA/LA体积和粒子流量进行分析.
- 血栓和非血栓组之间的流动动态的比较.
主要成果:
- 在LAA中的总颗粒数量是血栓和非血栓组之间的关键差异化因素.
- 光伏角度极大地影响流入LAA的流量,影响血栓风险.
- 将LAA与左上方PV对齐或右上方PV倾斜会影响血栓形成.
结论:
- 光伏配置和方向是LAA血流和血栓形成的重要决定因素.
- 针对患者的CFD模拟显示了静脉解剖学,LAA形态和凝块风险之间的复杂联系.
- 综合的血液动力学分析对于理解AF相关的血栓形成至关重要.
相关概念视频
01:21Coronary Circulation
2.7K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
2.7K
01:11Overview of Systemic Veins
465
Systemic veins are crucial blood vessels that return deoxygenated blood from various body tissues back to the heart. There are three systemic veins that return deoxygenated blood to the heart, they are as follows.
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the...
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the...
465
01:19Overview of Pulmonary Circulation
1.2K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
1.2K
01:15Overview of Systemic and Pulmonary Circulation
4.3K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
The oxygenated blood is sent...
4.3K
01:19Veins of Thorax
796
The azygos system is a crucial part of the body's circulatory system and drains most of the thorax. It comprises the azygos, hemiazygos, and accessory hemiazygos veins.
The azygos vein, positioned just right of the midline and anterior to the vertebral column, begins at the junction of the right ascending lumbar and subcostal veins, terminating in the superior vena cava. This vein drains blood from the right side of the thoracic wall, thoracic viscera, and posterior abdominal wall.
The...
The azygos vein, positioned just right of the midline and anterior to the vertebral column, begins at the junction of the right ascending lumbar and subcostal veins, terminating in the superior vena cava. This vein drains blood from the right side of the thoracic wall, thoracic viscera, and posterior abdominal wall.
The...
796
01:11Overview of Systemic Arteries
812
The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the...
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the...
812