2型糖尿病对认知表现的影响:评论的综述
Teppo Sola1,2, Fanny-Maria Sola3, Mervi Jehkonen4,3
1Psychology, Tampere University, Tampere, Finland. teppo.sola@tuni.fi.
International journal of behavioral medicine
|March 12, 2024
概括
2型糖尿病与多个领域的认知能力下降有关. 然而,现有的审查存在方法上的缺陷,需要高质量的元分析,以更清楚地理解这种关联.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病经常与认知缺陷有关.
- 关于这个主题的现有系统审查在方法,质量和发现方面表现出显著的异质性.
- 这种异质性使研究人员和临床医生复杂化信息的合成.
研究的目的:
- 与健康对照人群相比,对现有的系统性审查进行系统性审查,检查2型糖尿病和认知能力下降之间的关联.
- 评估目前关于2型糖尿病和认知功能的文献质量和研究结果.
主要方法:
- 按照预先注册的协议,在四个主要数据库中进行了系统搜索.
- 九个系统性审查 (七个元分析,两个叙事综合) 符合纳入标准.
- 对每个包括的评论进行了偏差风险评估,并报告了带有置信区间的效果大小.
主要成果:
- 所有审查的研究都表明2型糖尿病与认知能力下降之间存在关联.
- 在最大的元分析中,效应大小通常很小或可以忽略不计.
- 注意力,执行功能,记忆,处理速度和工作记忆是最常被研究的认知领域.
- 所有包括的审查都存在方法上的局限性和高或不清楚的偏差风险.
结论:
- 2型糖尿病与各种领域和年龄组的认知表现下降有关.
- 需要按照PRISMA指南进行高质量的元分析.
- 未来的审查应该包括敏感性和子组分析,以解决偏见风险和研究异质性,并检查更广泛的认知功能.
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