双暴露和高尿血的关联基于人类研究和动物实验
Yue Gao1,2, Lei Bi1, Aijing Li1
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Science, Beijing 100085, China.
Environmental science & technology
|March 12, 2024
概括
暴露于某些双化学品 (BPs) 与更高的尿酸 (UA) 水平有关. 双S和P分别损害脏和肝脏,增加UA,而双F不会影响UA水平.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 超尿血,标志着血尿酸 (UA) 的升高,与各种疾病有关.
- 流行病学研究表明,环境污染物和高尿血症之间存在联系.
- 化学物质暴露,特别是双在高尿血症发展中的特定作用需要进一步研究.
研究的目的:
- 为了研究双 (BP) 暴露对超尿血病发生的影响.
- 为了确定与UA水平升高相关的特定双化学物质.
- 阐明BP影响UA恒温的机制.
主要方法:
- 检测了15种双化学物质在人类血清和尿液样本中,这些样本来自中国的高血尿过高发病率地区.
- 血清UA度与检测到的双醇度之间的相关性分析.
- 在小鼠体内研究以评估双S (BPS),双P (BPP) 和双F (BPF) 暴露对血清UA水平和/肝功能的影响.
主要成果:
- 血清UA水平与尿路BPS,尿路BPP和血清BPF正相关.
- 在小鼠中,BPS和BPP暴露导致了血清UA水平的增加.
- BPS通过破坏脏结构增加UA; BPP通过破坏肝脏纯素代谢增加UA.
- 暴露于BPF并没有提高血清UA水平,因为它抑制了瓜宁转化为UA.
结论:
- 暴露于BPS和BPP可通过涉及脏和肝脏通路的独特机制显著增加血清UA水平.
- 不过,BPF似乎并没有通过纯素代谢导致高尿血症.
- 这些发现突显了对UA恒温的双暴露的潜在风险,并提供了机理性的见解.
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