结直肠手术后的全身炎症和急性损伤
John D Mannion1, Assar Rather2, Adrianne Fisher2
1Bayhealth Medical Center, Dover, DE, United Kingdom. mannionjd@yahoo.com.
BMC nephrology
|March 12, 2024
概括
系统性炎症在结直肠外科手术患者中显著导致急性损伤 (AKI). 管理早期的术后炎症可能会改善患者的康复并减少并发症.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 外科手术炎症 在外科手术炎症.
- 临界护理医学 临界护理医学
背景情况:
- 研究了1224名结直肠手术患者中急性损伤 (AKI) 中系统性炎症的作用.
- 评估了降低术后炎症以减轻AKI风险的潜力.
研究的目的:
- 确定系统性炎症作为结直肠外科手术中AKI的原因的相对重要性.
- 评估炎症标志物与AKI发展和并发症之间的关联.
主要方法:
- 对1224名结直肠外科手术患者的回顾性审查.
- 使用病改善全球结果 (KDIGO) 标准进行AKI分类.
- 分析炎症标志物,包括术后白细胞计数 (POD #1 WBC) 和中性粒细胞与淋巴细胞的比率 (POD #1 NLR),以及手术持续时间,使用多变量逻辑回归.
主要成果:
- AKI发生在24.6%的患者中.
- 手术后炎症标志物 (POD #1 WBC和POD #1 NLR) 独立地与AKI相关 (P < 0.0001).
- 炎症预测了与AKI相关的并发症,包括感染,慢性功能衰竭和停留时间的延长.
结论:
- 系统性炎症是结直肠手术患者AKI的重要独立预测因子.
- 减少早期的术后炎症是改善患者治疗结果和预防AKI的潜在策略.
相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
184
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
184
Appendicitis-II: Diagnostic Studies and Management
80
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
80
Inflammatory Bowel Disease II: Crohn's Disease
244
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
244
Inflammation
53.4K
Overview
53.4K
Inflammatory Bowel Disease V: Surgical Management
145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
145


