关于核心成果集 (COS) 开发的系统审查的方法质量
Hong Cao1,2, Yan Chen1,2, Zhihao Yang3
1School of Pharmaceutical Sciences, Guizhou University, 2708 South of Huaxi Avenue Road, Guiyang, China.
BMC medical research methodology
|March 12, 2024
概括
开发核心成果集 (COS) 的系统审查 (SRs) 显示方法质量不佳. 坚持最佳方法对于可靠的COS开发至关重要,尤其是在使用协议时.
科学领域:
- 临床研究方法论 临床研究方法论
- 证据综合 证据综合
- 健康 结果 研究 研究 结果
背景情况:
- 核心结果集 (COS) 旨在标准化临床试验中的结果措施.
- 系统审查 (SRs) 是 COS 发展的基础.
- 用于COS开发的SR的方法质量尚未得到一致的评估.
研究的目的:
- 调查在COS开发中使用的SRs的状态.
- 评估这些SRs的方法质量.
主要方法:
- 在PubMed中搜索与COS开发相关的SRs (开始至2022年5月).
- 在SRs. 内的疾病和研究的定性总结.
- 使用AMSTAR 2.0.0的方法质量评估.
- 使用曼-惠特尼U测试进行SR质量的比较,使用和不使用协议.
主要成果:
- 来自23个地区的175个SR,主要侧重于肌肉骨,损伤,消化,神经和泌尿生殖系统疾病.
- 大多数SR (88%) 包括RCT,但很少有 (23.38%) 评估偏差风险.
- 超过93%的SR通过AMSTAR 2.0.0获得了"非常低"至"低"的整体信心.
- 具有协议的SR显示总体信心明显高于没有协议的SR (P <.001).
结论:
- 发表的关于COS开发的SR的方法质量通常很差.
- 研究人员必须仔细选择疾病主题,并遵守支持COS的SRs的严格方法.
- 使用协议显著提高了用于COS开发的SRs的质量和可靠性.
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