对EMBOPIPE流量转移装置的评估:体内和体外实验
Yongnan Zhu1, Fanyan Zeng2, Jian Liu3
1Department of Beijing Neurosurgical Institute, Fengtai District, Capital Medical University, No. 119, South Fourth Ring West Road, Beijing, 100070, People's Republic of China.
Chinese neurosurgical journal
|March 12, 2024
概括
在临床前研究中,新型EMBOPIPE流量转移装置显示了高内动脉瘤封闭率,并保持了分支动脉通透性. 它的醇胆表面修饰减少了血小板粘附,提高了内血管治疗的安全性.
科学领域:
- 生物医学工程 生物医学工程
- 血管外科 血管外科
- 干预性放射学 干预性放射学
背景情况:
- 流量转移装置 (FDD) 已在内动脉瘤治疗中取得了先进的进展,但存在一些缺点.
- 新型FDD需要持续创新.
- 本研究评估了新型EMBOPIPE FDD的安全性和有效性.
研究的目的:
- 评估EMBOPIPE FDD的安全性和有效性.
- 为了评估动脉瘤堵塞和分支动脉通透度.
- 分析EMBOPIPE的血栓生成潜力和病理结果.
主要方法:
- 临床前研究使用20只带有诱导动脉瘤的子和9只带有腹部大动脉植入的子.
- 在28日,90日和180日随机随访.
- 在体外的钱德勒循环模型来比较EMBOPIPE的血栓发生率与裸体支架.
主要成果:
- 在95%的动脉瘤中成功部署.
- 动脉瘤闭塞率为73.3% (28d),83.3% (90d) 和100% (180d) 的情况.
- 维持动脉通透度,直径变化最小,病理正常;血小板对EMBOPIPE支架的粘附性降低.
结论:
- EMBOPIPE实现了高动脉瘤堵塞率和优异的分支动脉通透性.
- 显示出有利的病理结果,包括内皮细胞化和减少炎症.
- 修改EMBOPIPE的基胆可能会减少血栓形成.
相关概念视频
01:28Pipe Flowrate Measurement
In pipe flow measurement, orifice, nozzle, and Venturi meters are commonly used to determine fluid flowrates by constricting the flow area, which increases fluid velocity and reduces pressure. This pressure difference, governed by Bernoulli's principle and adjusted for real-world conditions, is essential for calculating flowrate. Each meter type is suited to specific applications based on accuracy, efficiency, and compatibility with various flow conditions.
The orifice meter is a simple,...
The orifice meter is a simple,...
01:26General External Flow Characteristics
The study of external flow is essential for creating structures and objects that interact efficiently and safely with moving fluids, such as air or water. When a body is immersed in a flowing fluid, it experiences two primary forces: drag, which opposes motion along the flow direction, and lift, which acts perpendicular to the flow. The shape, size, and orientation of the object influence these forces.Streamlined and Blunt Bodies in External FlowObjects in fluid flow are classified as...