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透析导管,血管和血液之间的相互作用的数值建模,考虑到弹性结构变形

Zihan Chen^1,2, Qijun Zheng^1,2, Zhenbo Tong^1,3

¹Southeast University-Monash University Joint Research Institute, Suzhou, China.

International journal for numerical methods in biomedical engineering

|March 12, 2024

概括

中枢静脉导管 (CVC) 由于血液流量发生变化,可能导致血栓和狭窄. 这项研究模拟了CVC植入,揭示了螺旋流和高壁切削应力 (WSS) 在导管尖附近,增加并发症风险.

科学领域:

生物医学工程生物医学工程
流体动力学流体动力学
医疗器械设计医疗器械设计

背景情况:

在患者体内的透析导管 (CVC) 存在巨大的血栓和狭窄形成的风险.
生物力学研究表明,血管壁剪切应力 (WSS) 是引发这些生理并发症的关键因素.

研究的目的:

评估CVC植入对中央静脉的血液动力学影响.
为了确定血液动力学环境的变化,与CVC安置后的血栓发育有关.

主要方法:

计算流体动力学 (CFD) 和有限元分析 (FEA) 用于模拟血液流动和血管力学.
从CT图像创建了一个特定于患者的Superior Vena Cava (SVC) 模型.
流体结构相互作用 (FSI) 模拟考虑了血管壁和血流之间的弹性相互作用,包括导管振动.

主要成果:

CVC 内置诱导螺旋和循环回流在导管尖端附近的血液流动模式.
高振荡切割指数 (OSI) 和WSS区域在导管尖端和血管结处被确定.
由于血压变化,观察到导管振动,振幅高达血管宽度的10%,这是由于血压变化.

结论:

CVC 植入显著改变了中央静脉血动力学,创造了有利于血栓形成的条件.
导管尖端及其与血管壁的相互作用是WSS和OSI升高的关键区域.
FSI模拟强调了在预测并发症时考虑血管壁变形性和导管运动的重要性.

关键词:

血液的流动,血液的流动.计算流体动力学的流体动力学.可以变形的船只.透析导管是用来进行透析的.流体结构的相互作用.

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