淋巴细胞与高密度脂蛋白比率和抑郁症之间的关联:来自NHANES 2015-2018年的数据
Junzhi Chen1, Yan Huang2, Xiaolin Li1
1Division of Nephrology, South China Hospital of Shenzhen University, Shenzhen, China.
Brain and behavior
|March 12, 2024
概括
较高的淋巴细胞与高密度脂蛋白 (LHR) 比率与美国成年人抑郁症风险增加有关. 这种关联在代谢综合征或BMI在25-30kg/m2之间的人中更强.
科学领域:
- 临床医学 临床医学
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- 淋巴细胞与高密度脂蛋白比率 (LHR) 和抑郁症之间的联系尚未得到充分证实.
- 现有的研究还没有最终澄清LHR在抑郁症中的作用.
研究的目的:
- 在美国成年人代表性样本中调查LHR和抑郁症之间的关联.
- 为了确定LHR是否可以作为抑郁风险的潜在生物标志物.
主要方法:
- 这是一项对来自国家健康和营养检查调查 (2015-2018) 的4216名参与者的横截面分析.
- 使用患者健康问卷-9 (PHQ-9) 评估的抑郁症状,得分≥10表示抑郁.
- 采用多重逻辑回归模型来分析LHR和抑郁症之间的关系,控制共变量.
主要成果:
- 在LHR和抑郁症之间观察到一个显著的积极关联 (aOR=1.31,95% CI [1.14,1.50]) 对于LHR标准偏差的增加.
- 分层分析显示,LHR与代谢综合征 (MetS) 和体重指数 (BMI) 之间有关抑郁风险的显著相互作用 (p < .05).
结论:
- 升高的LHR水平与美国成年人患抑郁症的可能性更高显著相关.
- 低体重和抑郁症之间的关联在患有MetS或BMI在超重范围 (2530 kg/m2) 内的个体中更为明显.
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