相关实验视频

Updated: Sep 14, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

中期肝细胞癌:改进次阶段或转变范式?

Bernardo Stefanini¹, Luca Ielasi², Dante Pio Pallotta¹

¹Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

Journal of liver cancer

|March 12, 2024

概括

巴塞罗那诊所肝癌分期系统的肝细胞癌 (HCC) 需要改进,特别是在中间阶段. 个性化治疗选择对于改善患者的治疗结果至关重要.

科学领域:

肝病学肝病学是一种肝病学.
在瘤学瘤学.
医疗分期系统医疗分期系统

背景情况:

成立于1999年的巴塞罗那诊所肝癌 (BCLC) 阶段系统指导肝细胞癌 (HCC) 治疗,但因其中间 (BCLC-B) 阶段异质性而受到批评.
已经提出了像Bolondi和Kinki标准这样的分类系统,以改进中间HCC分类并提高预后准确性.

研究的目的:

审查癌症中期HCC的癌症分期的演变.
评估当前分期系统的局限性以及对个性化治疗方法的需求.
评估中期HCC的治疗选择.

主要方法:

对HCC分期系统演变的文献综述.
对中等HCC的分类标准的分析.
讨论中级HCC的治疗范式和选择.

主要成果:

虽然BCLC分期系统是基础性的,但由于患者群体的异质性,需要对中级HCC进行改进.
亚分类系统在预测结果方面表现出可变的成功.
转向个性化治疗选择的转变正在出现,而不是严格遵守阶段.

结论:

目前的分期系统,包括BCLC,需要加强中级HCC.
个性化治疗策略,考虑到个体患者的因素,对于最佳的HCC管理至关重要.
多学科的方法对于定制治疗和改善HCC患者的存活率至关重要.

关键词:

肝细胞癌,肝细胞癌.中间阶段,分阶段系统.

更多相关视频

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

相关概念视频

Cirrhosis II: Pathophysiology

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...