(L.) 对神经疾病的植物药理潜力:进展和前景
Jyotsana Dwivedi1, Pankaj Kumar2, Pranjal Sachan1
1Department of Pharmacy, PSIT-Pranveer Singh Institute of Technology Pharmacy, Bhauti, Kanpur-209305, UP, India.
Recent advances in food, nutrition & agriculture
|March 12, 2024
概括
(bael) 提取物通过改变导致神经元损伤的细胞机制来显示神经保护性益处. 这种传统的印度植物对阿尔茨海默氏症等神经退行性疾病具有治疗意义.
科学领域:
- 民族植物学 民族植物学
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- (Aegle marmelos) 是一种传统的印度植物,已有5000年的药用历史.
- 它的叶子,树皮,根和果实在阿尤尔韦达和民间医学中用于治疗各种疾病.
- 现代研究证实了贝尔由于其生物活性化合物的治疗作用.
研究的目的:
- 审查Aegle marmelos的地理分布,形态和治疗益处.
- 探索贝尔中的植物化学物质及其在神经疾病中的药理应用.
- 巩固现有的关于贝尔在治疗神经退行性疾病方面的潜力的文献.
主要方法:
- 在PubMed,Google Scholar,ScienceDirect,Elsevier和威利在线图书馆进行全面的文献搜索.
- 关键词包括"A. marmelos"",地理分布"",民族植物学用途"",植物成分"和"神经保护活动".
- 专注于1975年至2023年间发表的审查论文,其中包括A. marmelos对神经疾病的子集.
主要成果:
- 海提取物显示出潜在的神经保护性益处.
- 这些好处源于植物调节参与神经元损伤的细胞机制的能力.
- 有证据表明,它在抵消氧化应激和认知缺陷方面发挥着作用.
结论:
- 神经退行性疾病会导致不可逆转的神经元损失和功能障碍.
- A. marmelos 提取物和化合物在焦虑,,抑郁症,帕金森病和阿尔茨海默病的模型中表现有前途.
- 贝尔对STZ诱导的氧化应激和认知损失的神经保护作用突显了它对阿尔茨海默病的治疗意义.
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