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重复的费纳斯特里德药物给药促进了突触可塑性,并在雌性大鼠中产生了抗抑郁药和焦虑缓解剂类效应

Jose Nayana¹, Byrathnahalli S Shankaranarayana Rao¹, Bettadapura N Srikumar¹

¹Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.

Journal of neuroscience research

|March 12, 2024

概括

在雌性大鼠中,费纳斯特治疗显示出抗抑郁和抗焦虑作用,可能通过改变雌激素和皮质水平. 需要进一步的研究,以了解治疗女性神经精神疾病的神经类固醇机制.

科学领域:

神经内分泌学神经内分泌学
药理学药理学是指药理学的学科.
行为神经科学行为神经科学

背景情况:

费纳斯特抑制了5α-减少酶,影响了神经类固醇生物合成.
费纳斯特对女性和雌性动物的心理健康影响在很大程度上是未知的.
现有关于费纳斯特神经类固醇生成效应的研究主要集中在男性身上.

研究的目的:

为了研究反复给予费纳斯特对雌性大鼠的行为,血类固醇水平和突触可塑性的影响.
在雌性动物模型中探索费纳斯特的潜在抗抑郁药和焦虑缓解剂效果.
阐明神经类固醇,如雌激醇和皮质在费纳斯特所观察到的影响中的作用.

主要方法:

雌性大鼠每天接受皮下芬胺 (10,30或100毫克/公斤) 六天.
行为测试包括强迫游泳测试 (FST),喷测试,新性抑制养任务 (NSFT),升高加迷宫 (EPM),开放场测试 (OFT) 和明暗测试 (LDT).
血类固醇水平 (雌激醇,皮质) 通过ELISA测量,并使用现场潜力记录评估海马突触可塑性.

主要成果:

费纳斯特的使用降低了FST中的不动性,表明了类似抗抑郁药的效果.
费纳斯特降低了NSFT中食的延迟时间,这表明它具有类似焦虑缓解剂的效果.
观察到血雌激醇的显著增加和皮质的减少,以及海马长期增强的潜能.

结论:

在雌性大鼠中,反复给予费纳斯特会表现出类似抗抑郁药和抗焦虑药的特性.
这些行为效应可能由雌激醇的增加和/或皮质水平的降低介导.
这些发现表明,芬纳斯特在开发女性神经精神疾病的新型神经类固醇治疗中具有潜力,这需要进一步的机制研究.

关键词:

这是一种5α-减少酶抑制剂.RRID:SCR_0142899 这是一个很好的例子.RRID:SCR_000441 一个问题 RRID:SCR_002798 这是一个很大的问题.RRID:SCR_00859090 这是一个很大的问题.RRID:SCR_01684242 这是一个很大的问题.RRID:SCR_018453 在线播放 RRID:SCR_01894444 这是一个很大的问题.RRID:SCR_01894545 这是一个很大的问题.RRID:SCR_01894646 这是一个很大的问题.RRID:SCR_01894747 这是一个很大的问题.RRID:SCR_01895050 这是一个很大的问题.RRID:SCR_018955 在线观看 RRID:SCR_018956 在线观看 RRID:SCR_01902828 这是一个很大的问题.皮质类皮质类固醇.雌二醇是雌二醇的一种药物.长期增强潜力长期增强潜力配对脉冲的促进作用

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