马歇尔静脉周围的自主神经:一项具有临床意义的死后研究
Denis Depes1,2, Ari Mennander2,3, Paavo Immonen1,2
1Department of Pathology, Fimlab Laboratories, Tampere, Finland.
概括
在心房动 (AF) 和心脏病患者中,马歇尔静脉 (VOM) 周围增加了交感神经和神经生长. 这表明VOM自主内尔化是心脏病的关键因素.
科学领域:
- 心血管病理学心血管病理学
- 自主神经系统研究 自主神经系统研究
- 心脏电生理学 心脏电生理学
背景情况:
- 马歇尔静脉 (VOM) 是胚胎左上腔静脉的残余,因其在心脏病中的作用而越来越受认可.
- 自主内置在心脏功能和心律失常发生中起着至关重要的作用,特别是在心房动 (AF) 中.
- 了解VOM的神经和纤维特征对于阐明其对心脏病理的贡献至关重要.
研究的目的:
- 分析马歇尔静脉 (VOM) 在人体尸检心脏中的自主内化和间歇性纤维化.
- 为了将这些形态发现与临床数据相关联,包括心房动 (AF) 和死亡原因.
- 阐明VOM相关的自主神经在心脏病的发病过程中的作用.
主要方法:
- 人体尸检心脏 (n=23) 使用免疫组织化学检查了交感神经 (铁氨酸氧化酶),副交感神经 (胆酸转移酶),神经生长 (GAP-43) 和一般神经标记物 (S100).
- 间歇性纤维化被评估使用马森三色染色.
- 进行了形态测量分析和与临床数据的相关性,包括AF史和死亡原因.
主要成果:
- 在所有与VOM相邻的区域中观察到丰富的交感内化.
- 伴随着心肌梗塞,心血管死亡和心肌梗塞的病史,伴随着伴随着心肌梗塞周围的VOM和神经生长的增加.
- 间歇性纤维化与年龄和心脏重量呈正相关性,并与AF和心血管死亡有关.
结论:
- 马歇尔静脉 (VOM) 在相邻区域表现出显著的自主内化,特别是同情性.
- 在VOM区域增强的交感内置和神经生长与心房动和其他心血管疾病有关.
- 这些发现突显了VOM作为治疗点的潜力,用于调节心脏病的自主影响.
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