前额叶皮质的直接电流刺激在渐进性超核麻中无效:一项随机试验
Arianna Cappiello1, Filomena Abate1, Sarah Adamo2,3
1Center for Neurodegenerative diseases (CEMAND), Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Fisciano, Italy.
概括
跨直流刺激 (tDCS) 在渐进性上核性麻 (PSP) 患者中没有改善口语或语义流. 治疗与恶化的行为症状有关,表明它对PSP无效.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 临床试验 临床试验
背景情况:
- 渐进性超核性麻 (PSP) 是一种罕见的4R-tauopathy.
- 超直流刺激 (tDCS) 正在研究神经系统疾病的症状改善.
研究的目的:
- 评估PSP患者在左脊侧前额皮层 (DLPFC) 上的阳道tDCS的短期,中期和长期疗效.
- 这项随机,双盲,假控制试验评估了tDCS对语言和语义流等主要结果的影响.
主要方法:
- 25名PSP患者在2周内每周5天接受活跃或假的tDCS (20分钟2mA) 2周.
- 评估是在基线,治疗后,45天和3个月进行的.
- 使用协差分析分析分析了有效性.
主要成果:
- 在使用活性tDCS时,没有观察到语言或语义流性的显著改善.
- 积极刺激与特定行为投诉的恶化有关.
结论:
- 一个为期2周的阳道左DLPFC tDCS协议对治疗PSP无效.
- 该研究强调了设计PSP症状临床试验的挑战.
- 可能需要进一步的研究来探索替代的tDCS协议或患者群体.
更多相关视频
08:22Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
Published on: October 7, 2017
8.1K
08:54Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
227
相关概念视频
Atomic Nuclei: Nuclear Relaxation Processes
In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis, the precessing magnetic moments are randomly oriented around the z-axis. This...
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
