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牛奶衍生的外体会影响DSS诱导的结肠炎小鼠的肠道微生物群
Tonghao Li1, Xiaolin Chen1, Qien Qi1
1School of Life Science and Engineering, Foshan University, No. 33 Guangyun Road, Nanhai District, Foshan, Guangdong China.
Indian journal of microbiology
|March 12, 2024
概括
牛奶衍生外体 (MDEs) 对患有德克斯硫酸盐 (DSS) 诱导的大肠炎的小鼠的肠道微生物群产生了积极影响. MDEs有助于维持微生物多样性,并改变了特定的细菌种群,这表明大肠炎的潜在治疗益处.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 生物技术是生物技术.
背景情况:
- 炎症性肠道疾病,包括大肠炎,是一个重大的健康问题.
- 肠道微生物群失生症在结肠炎的发病过程中起着至关重要的作用.
- 从牛奶 (MDEs) 中获得的外体正在研究它们的治疗潜力.
研究的目的:
- 为了研究MDEs对肠道微生物群组成的影响,在DSS诱导的大肠炎的小鼠模型中.
- 评估MDEs在缓解与大肠炎相关的肠道失调症方面的潜力.
主要方法:
- 使用Dextran硫酸 (DSS) 诱导的大肠炎小鼠模型.
- 向治疗组口服使用MDEs.
- 分析了肠道微生物群的组成,使用16S rRNA基因测序.
主要成果:
- DSS诱导的大肠炎显著降低了料摄入量和肠道微生物多样性 (香农指数).
- 与对照组相比,MDE的使用并没有显著改变料摄入量或Shannon指数.
- 随着MDEs的增加, *Campylobaterota*和*Lachnospiraceae_UCG_006*的相对丰度有所增加.
结论:
- 口服MDE给药对DSS诱导的大肠炎小鼠的肠道微生物群产生了积极的调节.
- MDEs显示出恢复某些由DSS改变的细菌种群的趋势.
- 这些发现表明,MDEs对预防和治疗大肠炎有前途.
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