在中国开发和验证2型糖尿病患者轻度认知障碍风险评分:一个实用的认知预选工具
Qun Ding1,2,3,4, Congcong Yu2,3, Xiang Xu1,3
1Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, People's Republic of China.
概括
一个新的风险评分有效地识别了2型糖尿病患者的轻度认知障碍 (MCI),使用年龄,教育,HbA1c,低血糖史和微血管疾病. 这个工具有助于在糖尿病护理中早期发现MCI.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 糖尿病,特别是2型糖尿病 (T2DM),与认知障碍的风险增加有关.
- 在T2DM患者中早期发现轻度认知障碍 (MCI) 对于及时干预至关重要.
研究的目的:
- 开发和验证一种多变量风险评分模型,用于识别T2DM患者的MCI.
主要方法:
- 一项涉及中国1256名T2DM住院患者的横截面研究.
- 基于NIA-AA标准和MoCA分数 (19-25) 的MCI诊断.
- 后勤回归用于识别预测因素;开发并验证了风险得分.
主要成果:
- 风险评分包括年龄,教育,HbA1c,严重低血糖史和微血管疾病.
- 该模型表现出良好的预测能力,AUC为0.751 (衍生) 和0.776 (验证).
- 该得分有效地将患者分为低,中,高MCI风险类别.
结论:
- 经过验证的风险评分有效评估T2DM成年人的MCI风险.
- 这种工具可以作为一种实际的预选方法,用于在常规糖尿病护理中早期检测MCI.
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