在短期和慢性失眠障碍之间,thalamic亚区域的左侧功能连接性减少
Xiaofen Ma1, Shishun Fu1, Guang Xu2
1Department of Medical Imaging, Guangdong Second Provincial General Hospital, No.466 Road XinGang, Guangzhou, 510317 People's Republic of China.
Sleep and biological rhythms
|March 12, 2024
概括
短期和慢性失眠障碍在thalamic亚区域表现出明显的和重叠的休息状态功能连接性 (RSFC) 变化,影响平行边缘区域并与嗜睡相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 失眠障碍 (ID) 是一种普遍的疾病,影响全球数百万人.
- 胸膜子区域在睡眠调节和认知功能中起着至关重要的作用.
- 了解不同类型的ID的神经基础对于有针对性的治疗至关重要.
研究的目的:
- 在短期和慢性失眠障碍 (ID) 中,系统地调查胸膜子区域的结构和功能异常.
- 为了检查这些体变化的临床相关性.
- 为了比较短期ID,慢性ID和健康对照 (HCs) 之间的发现.
主要方法:
- 招募了34名短期ID患者,41名慢性ID患者和46名HC患者.
- 使用灰色物质 (GM) 容量和基于种子的静止状态功能连接 (RSFC) 分析,用于特定的thalamic亚区域.
- 采用斯皮尔曼相关性来评估胸膜变化与临床变量之间的关系.
主要成果:
- 与HC和慢性ID相比,短期ID组在特定的乳头亚区域 (左cTtha,lPFtha,Otha,Pptha) 和双边尾状之间显示较低的RSFC.
- 在两组ID中都观察到左侧cTtha和Otha与右侧近海马环的交汇RSFC变化.
- 在左侧Otha-caudate RSFC和爱普沃思睡眠度量得分 (r=0.340,P=0.040) 之间发现了正相关性.
结论:
- 共有的和独特的RSFC变化存在于thalamic亚区域,连接到跨短期和慢性失眠障碍的双边区域.
- 这些发现突出了不同但重叠的神经机制,有助于不同类型的失眠.
- 该研究提供了对失眠病理生理学的见解,可能指导未来的治疗策略.
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