在精子参数和性激素上对无活化SARS-CoV-2疫苗的全面评估
Yehao Dong1, Zaihua Ba2, Yining Qin2
1Center for Reproductive Medicine, Affiliated Hospital of Jining Medical University, Jining, China.
Frontiers in immunology
|March 12, 2024
概括
无活化的SARS-CoV-2疫苗接种不会损害男性的生育能力. 疫苗接种后,精液参数和大多数性激素水平保持稳定,这为计划怀孕的男性提供了保证.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 疫苗学 疫苗学 疫苗学
- 安德罗学与人类学
背景情况:
- 无活化SARS-CoV-2疫苗的广泛使用需要对其对男性生殖健康的影响进行评估.
- 以前对mRNA疫苗的研究引发了担忧,强调需要评估非活化疫苗的安全性.
- 对无活化SARS-CoV-2疫苗对男性生育能力的影响进行全面分析至关重要.
研究的目的:
- 调查无活化SARS-CoV-2疫苗接种对男性生育能力参数的影响.
- 为了比较接种和未接种疫苗的男性的精液质量和性激素水平.
- 提供有关无活化COVID-19疫苗的生育建议的数据.
主要方法:
- 409名男性的回顾性队列研究 (2021年7月至2023年3月).
- 纳入标准:不同疫苗接种情况,没有先前的SARS-CoV-2感染.
- 疫苗接种前后评估性激素水平和精液参数.
主要成果:
- 在一次剂量组中,卵泡刺激激素 (FSH) 和益生菌素 (PRL) 水平升高.
- 没有观察到其他性激素或大多数精液参数 (体积,度,运动性,形态) 的显著变化.
- 总精子运动率在1+2剂后显著下降,但仍在正常范围内.
结论:
- 不活化SARS-CoV-2疫苗接种,单剂或组合剂,不会对男性生育能力产生负面影响.
- 这些发现可以让男性对接种疫苗后的生育能力感到放心.
- 这项研究支持将非活化疫苗安全数据纳入生育指南.
相关概念视频
Spermatogenesis
102.4K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.4K
Infertility in Males
262
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
262
Sperm Structure and Semen Composition
2.1K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
2.1K


