艾滋病毒和COVID-19:两种流行病具有显著的 (但不同的) 中枢神经系统并发症
Shino Magaki1, Ting Zhang1, Karam Han1
1Section of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles CA, USA.
Free neuropathology
|March 12, 2024
概括
艾滋病毒和SARS-CoV-2引起的神经疾病是显著的. 虽然艾滋病毒是艾滋病毒.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 神经病理学神经病理学
背景情况:
- 人类免疫缺陷病毒 (HIV) 和严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 已知会导致严重的神经系统疾病.
- 艾滋病毒的中枢神经系统 (CNS) 侵袭得到了充分的记录,但SARS-CoV-2对大脑的急性影响仍然不清楚.
- 描述了活跃的艾滋病毒感染的神经病理特征,与急性COVID-19中的大部分非特异性发现形成鲜明对比.
研究的目的:
- 研究艾滋病毒相关神经认知障碍 (HAND) 和后COVID条件 (PCC) 中慢性功能障碍的未知神经病理基质.
- 在联合抗逆转录病毒疗法时代,解决关于HAND的神经病理学研究的不确定的发现.
- 要强调没有公布的对被诊断为PCC的患者的尸检研究.
主要方法:
- 现有神经病理学研究对HAND的审查.
- 对急性SARS-CoV-2神经病理学现有文献的分析.
- 在HIV和SARS-CoV-2感染中识别有关慢性神经认知功能障碍的知识差距.
主要成果:
- 在HAND和PCC中慢性功能障碍的神经病理基质目前尚不清楚.
- 目前对HAND的神经病理学的研究已经产生了不确定的结果.
- 专门针对PCC患者的尸检研究尚未发表.
结论:
- 进一步的纵向,多学科研究对于理解HAND和PCC中中枢神经系统功能障碍机制至关重要.
- 涉及对照组的比较神经病理学研究是有必要的.
- 阐明HAND和PCC等慢性疾病的神经病理学对于开发有效的治疗方法至关重要.
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