在阻塞性睡眠呼吸暂停患者中,白天和夜间血甲氧素A水平和认知功能之间的关联
Jing Zhu1,2, Zhaofu Zeng1, Mengqing Xiong1
1Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei China.
Sleep and biological rhythms
|March 12, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 患者的血甲氧素A (OXA) 水平较低,与认知障碍相关. 白天OXA可能有助于诊断OSA的认知问题.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 生物化学 生物化学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与认知缺陷有关,但潜在的机制,特别是涉及像素A (OXA) 这样的神经质,尚未完全理解.
- 血OXA水平及其与OSA患者认知功能的关联需要进一步调查.
研究的目的:
- 调查白天和夜间血OXA水平与OSA患者的认知功能之间的关系.
- 评估血OXA水平的诊断价值,以确定OSA的认知障碍.
主要方法:
- 106名受试者接受了多睡眠测试 (PSG),蒙特利尔认知评估 (MoCA) 和爱普沃思睡眠度量表 (ESS).
- 使用ELISA测量了血OXA水平.
- 用接收器运行特征 (ROC) 曲线来确定诊断效用.
主要成果:
- 与对照组相比,OSA患者的MoCA得分和血OXA水平较低 (p < 0.01).
- 在OSA中,认知障碍与白天和夜间OXA水平显著降低有关 (p <0.01).
- 血OXA水平与MoCA得分和SaO2正相关,与AHI和氧气脱度指数负相关.
结论:
- 血OXA度可能与OSA患者的认知功能有关.
- 白天血OXA水平显示出诊断价值,用于评估OSA的认知障碍,最佳值为49.34ppg/ml (80.0%灵敏度,74.3%特异性).
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