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在鼻到脑运输后,灵长类大脑中胰岛素的分布

Kylie Smith^1,2, Jinda Fan^2,3,4, Gwendolyn A Marriner⁵

¹Department of Biomedical Engineering Michigan State University East Lansing Michigan USA.

Alzheimer's & dementia (New York, N. Y.)

|March 12, 2024

概括

针对阿尔茨海默病 (AD) 的鼻至大脑 (N2B) 胰岛素输送,使用PET成像进行了非侵入性跟踪. 液体导管输送被证明比气溶方法更有效,用于大脑吸收[18F]FB-胰岛素.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
医疗成像医学成像

背景情况:

鼻至大脑 (N2B) 胰岛素输送显示出阿尔茨海默病 (AD) 治疗的前景.
非侵入性方法对于跟踪N2B交付和临床实施至关重要.
定子发射断层扫描 (PET) 为监测N2B药物运输提供了一个潜在的解决方案.

研究的目的:

评估跟踪N2B胰岛素输送到大脑的非侵入性方法.
为了比较[18F]FB-胰岛素的不同N2B输送方法的效率.
评估非人类灵长类动物内鼻输送[18F]FB胰岛素的大脑吸收和分布.

主要方法:

[18F]FB-胰岛素是通过三种N2B输送方法合成和管理的:气溶 (管道/导管) 和液体 (导管).
动态PET成像 (120分钟) 用于量化鼻腔和全脑传递效率.
在Cynomolgus中分析了区域大脑吸收,以确定[18F]FB-胰岛素分布.

主要成果:

通过导管灌注液体在受试者和大脑输送方面显著优于气溶方法.
鼻内注射的[18F]FB胰岛素迅速穿过状板,在13分钟内到达边缘和前大脑区域.
标记物的半衰期在具有高胰岛素受体密度的嗅觉投射部位中更长.

结论:

导管式液体输送与PET成像相结合,为跟踪N2B [18F]FB-胰岛素提供了一种可行的方法.
这种方法广泛适用于评估其他N2B治疗剂.
该方法促进了N2B胰岛素用于AD治疗的快速临床评估.

关键词:

阿尔茨海默氏症的疾病是阿尔茨海默氏症.头骨神经头骨神经头骨神经形板是指一个形板.痴呆症痴呆症是一种痴呆症.动态成像图像处理系统以图像为导向的交付方式.干预干预干预干预干预干预鼻腔内注射胰岛素的使用方法神经保护神经保护非侵入性成像成像技术定子发射断层扫描 (PET) 是一种

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