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解码选择性:对AKR1B1和AKR1B10抑制的计算洞察力

Mingyue Liu1, Xiaochun Qin1, Jing Li1

  • 1Department of Drug Clinical Research Center, The First Affiliated Hospital of Shandong Second Medical University, Weifang 261000, China. wangzhiliang1977@126.com.

Physical chemistry chemical physics : PCCP
|March 12, 2024
PubMed
概括

设计针对非常相似的蛋白质的选择性抑制剂,如人类的阿尔多基因还原酶 (AKRs),至关重要. 这项研究使用计算方法来了解AKR1B1/10的选择性,有助于开发更安全的癌症和糖尿病药物.

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