长期或复杂的mpox在没有控制的HIV感染的患者
Anaïs Corma-Gómez1,2,3, Alfonso Cabello4, Eva Orviz5
1Instituto de Biomedicina de Sevilla (IBiS)/CSIC, Sevilla, Spain.
Journal of medical virology
|March 12, 2024
概括
没有控制的艾滋病毒感染的艾滋病毒感染者 (PLWH) 面临着明显更高的长期或复杂 (LC) 感染的风险. 及时进行艾滋病毒检测和启动抗逆转录病毒治疗 (ART) 对于减轻PLWH中mopox严重程度至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 有限且有争议的研究存在于艾滋病毒对mpox结果的影响.
- 了解这种关系对于在脆弱人群中管理mpox至关重要.
研究的目的:
- 评估人类免疫缺陷病毒 (HIV) 感染对mpox.com的临床过程的影响.
- 在一大批西班牙患者队列中确定长期或复杂 (LC) mpox 的危险因素.
主要方法:
- 全国范围的病例系列研究包括2022年4月至2023年6月的1823名PCR确诊mpox患者.
- 定义LC mpox为临床疗程持续时间≥28天,传播疾病或严重并发症.
- 分析了786名艾滋病毒感染者 (PLWH) 的数据,并将结果与没有艾滋病毒的人进行了比较.
主要成果:
- 血HIV-RNA≥1000副本/毫升的PLWH具有显著更高的LC mpox风险 (调整后OR=4.06).
- 无法控制的艾滋病毒感染 (缺乏有效的抗逆转录病毒疗法 - - 抗逆转录病毒疗法) 与LC mpox有很强的关联.
- 控制HIV的PLWH与没有HIV的个体之间没有观察到LC mpox的显著差异.
结论:
- 在PLWH中不受控制的HIV感染增加了长期或复杂的mpox发展的风险.
- 建议对mopox患者进行紧急的HIV检测,并建议对HIV阳性个体及时启动ART.
- 确保获得和遵守ART对于改善PLWH中mpox结果至关重要.
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