在功能性运动障碍中,下降抑制性知觉通路的异常
Giovanna Squintani1, Christian Geroin2, Alessia Pasquali2
1Neurology and Neurophysiology Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
概括
功能运动障碍 (FMD) 患者表现出正常的上升疼痛路径,但受损的下降疼痛抑制. 这表明下降的疼痛抑制控制缺陷有助于口病的疼痛.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 运动障碍 运动障碍
背景情况:
- 疼痛是功能性运动障碍 (FMD) 的常见和衰弱的非运动症状.
- 了解口炎的疼痛机制对于有效管理至关重要.
研究的目的:
- 在口病患者中使用激光唤起潜能 (LEP) 调查上升和下降的感知途径.
- 探索条件疼痛调制 (CPM) 在口炎疼痛中的作用.
主要方法:
- 一个"自下而上,自上而下"的有害范式被采用,包括CPM.
- 激光唤起潜力 (LEPs),特别是N2/P2振幅,记录在21名口病患者和20名对照组中.
- 在基线,在异型有害条件刺激 (HNCS) 期间和HNCS后,对上肢和下肢进行了刺激.
主要成果:
- 升的疼痛途径在口炎患者中似乎正常.
- 在口病患者中观察到减少的CPM反应,以较低的N2/P2幅度减少为标志.
- 与健康对照组 (HC) 相比,口病患者的N2/P2振幅比率显著更高.
结论:
- 在口炎的疼痛可能源于下降疼痛抑制控制的损害.
- 这些发现为口炎疼痛的病理生理学提供了新的视角.
- 针对下降性疼痛调制可能是治疗口病相关疼痛的治疗策略.
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