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基因表达可塑性,随后在高海拔环境中的殖民期间发生基因变化
Huishang She1, Yan Hao1, Gang Song1
1Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
eLife
|March 12, 2024
概括
侵入新环境的生物表现出基因表达的变化. 在欧亚树中,高海拔殖民期间的遗传适应性往往会逆转或加强对缺氧的可塑性.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 生理适应 生理适应
背景情况:
- 现型可塑性使物种能够殖民新的环境.
- "塑性第一"假设表明,最初的塑性变化可以在以后被遗传同化.
- 了解适应新环境时的基因表达变化至关重要.
研究的目的:
- 量化欧亚树的基因表达可塑性和监管适应性.
- 为了研究在高海拔殖民期间对低氧反应的基因表达变化是如何被修改的.
- 确定基因表达可塑性,肌肉表型和遗传差异之间的关系.
主要方法:
- 研究了低地 (祖先) 和高地 (殖民) 种群的欧亚树.
- 实验诱导的缺氧适应以评估塑性反应.
- 分析了心脏和飞行肌肉中的基因表达,与肌肉表现型相关.
主要成果:
- 与低氧耐受性相关的基因表达可塑性在被殖民群体中经常被逆转,而不是加强.
- 不适应性可塑性 (降低低氧耐受性) 减少,而适应性可塑性 (增加低氧耐受性) 得到加强.
- 具有显著强化或逆转的基因在祖先和殖民人口之间显示出更大的遗传差异.
结论:
- 在初始高海拔殖民期间的基因表达可塑性可以通过选择来逆转或加强.
- 殖民人口微调其基因表达以优化低氧耐受性.
- 这项研究强调了在进化过程中可塑性和遗传适应性之间的相互作用.
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